Chronic SIRT1 supplementation in diabetic mice improves endothelial function by suppressing oxidative stress
Enhancing SIRT1 activity exerts beneficial cardiovascular effects. In diabetes, plasma SIRT1 levels are reduced. We aimed to investigate the therapeutic potential of chronic recombinant murine SIRT1 (rmSIRT1) supplementation to alleviate endothelial and vascular dysfunction in diabetic mice (db/db).
Read full article (Cardiovascular Research (2023) 00, 1–12)