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Calcific aortic stenosis: omics-based target discovery and therapy development

Calcific aortic valve disease (CAVD) resulting in aortic stenosis (AS) is a significant driver of cardiovascular morbidity and mortality and encompasses a spectrum of early leaflet fibrosis and thickening [aortic valve (AV) sclerosis, present in ∼25% of seniors]...

Read full article (European Heart Journal (2024) 00, 1–15)

European Society of Cardiology Board 2024-2026

The ESC Board 2024 - 2026 under the presidency of Prof. Thomas F. Lüscher.

Learn more here!

The cardiologist in the age of artificial intelligence: what is left for us?

No doubt, AI will transform cardiology as it is a specialty integrating vast amounts of data on patient history, symptoms, ECGs, laboratory values, and imaging of all sorts. So, what is left for the physician?

Read full article (Cardiovascular Research (2024) 00, 1–3)

Proenkephalin improves cardio-renal risk prediction in acute coronary syndromes: the KID-ACS score

Circulating proenkephalin (PENK) is a stable endogenous polypeptide with fast response to glomerular dysfunction and tubular damage. This study examined the predictive value of PENK for renal outcomes and mortality in patients with acute coronary syndrome (ACS).

Read full article (European Heart Journal (2024) 00, 1–17)

Sex-specific prediction of cardiogenic shock after acute coronary syndromes: the SEX-SHOCK score

Cardiogenic shock (CS) remains the primary cause of in-hospital death after acute coronary syndromes (ACS), with its plateauing mortality rates approaching 50%. However, its sex-specific performance remains unknown, and refined risk prediction strategies are warranted.

Read full article (European Heart Journal (2024) 00, 1–15)

Inhibition of de novo ceramide synthesis by sirtuin-1 improves beta-cell function and glucose metabolism in type 2 diabetes

Obesity and type 2 diabetes (T2D) are major risk factors for cardiovascular (CV) diseases. Restoration of systemic SIRT1 may provide a novel therapeutic strategy to counteract toxic ceramide synthesis and mitigate CV complications of T2D.

Read full article (Cardiovascular Research (2024) 120, 1265–1278)
 

From a club of friends to an institution: past successes and future challenges for the European Society of Cardiology

In 1946 and again in 1948, during the second and third Inter-American Congress of Cardiology, a club of friends amongst the European participants discussed the creation of the European Society of Cardiology (ESC). The ESC was officially founded on 2 September 1950... 

Read full article (European Heart Journal (2024) 00, 1–3)

Artificial intelligence in cardiovascular medicine: clinical applications

This paper provides an overview of the current data revolution that has changed and will continue to change the face of clinical
medicine radically, if properly used, to the benefit of physicians and patients alike

Read full article (European Heart Journal - Cardiovascular Pharmacotherapy (2024) 00, 1–14)

Safety and effectiveness of glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: insights from the SPUM-ACS study

In this paper, the authors aimed to assess the utilization, effectiveness, and safety of GPI in a large prospective multicentre cohort of contemporary ACS patients.

Read full article (European Heart Journal - Cardiovascular Pharmacotherapy (2024) 0 , 1–12)

Cardiogenic shock: do we need a paradigm shift?

The paradigm shift in the management of cardiogenic shock: moving from pure mechanical left ventricular unloading to neurohumoral and anti- inflammatory blockade with or without left ventricular mechanical assistance...

Read full article (European Heart Journal (2024) 00, 1–3)