Professor Thomas F. Lüscher is Director of Research, Education & Development and Consultant of Cardiology at the Royal Brompton & Harefield Hospital Trust and Imperial College in London as well as Director of the Center for Molecular Cardiology of the University of Zurich. He is the foundation's founder and president.

Dr. Ruth Amstein is Director of the Zurich Heart House since 2009. She joined the Foundation for Cardiovascular Research as Director Education in 1998. She graduated in Pharmacy from the Swiss Federal Institute of Technology (ETH) Zurich and achieved her Ph.D. degree at the University of Basel on pathophysiological processes in the cardiovascular system. Ten years working experience in the pharmaceutical industry with responsibilities in regulatory affairs, clinical research and marketing. In 1991 she was a co-founder of the European Course of Pharmaceutical Medicine at the University Hospital Basel where she acted as Programme Director until 1997.

Hubert J. Beerli acts as CFO at the Foundation for Cardiovascular Research since July 2023. After a commercial apprenticeship and studies as a federally certified accountant he continued studies as expert for accounting and controlling which he finalized with diploma from SIB. He was engaged in different industries (transportation, trade, building technologies, chemical industry, education) in the capacity of controlling and commercial manager and head of finance. He gained international experience during nine years abroad in various countries.