Artificial intelligence (AI) is becoming increasingly important in cardiovascular medicine - but how does AI learn? Nucleic acid sequences contain building instructions for our organs, our body, and our self. Could an organism be reconstructed by such a blueprint? Reality proofs that it is complicated. Such complexity is beyond our mental capacity. Could Artificial Intelligence and Machine Learning (AI/ML) help? Thomas F. Lüscher and Florian A. Wenzl provide their perspective in the European Heart Journal.