Livius d’Uscio has studied pharmacy in Bern from 1988 to 1994 and then joined the cardiovascular research division of the Department of Cardiology at Inselspital Berne, Switzerland. During his stay, he made seminal contributions to understanding of the role of circulating peptides including endothelin and angiotensin II in the control of blood vessel tone and pathogenesis of hypertension and submitted his work as a Ph.D. thesis in pharmacy at the University of Berne. For his work, he received first prize for the best PhD thesis of that year of the University of Berne. In 1997, he moved to the cardiovascular research division of the Institute of Physiology at the University of Zurich to continue his work. He published extensively in peer-reviewed journals on endothelial regulation of resistance arteries and their alterations in hypertension and hypercholesterolemia. In 1999, he joined Prof. Zvonimir Katusic’s vascular molecular biology laboratory in the Department of Anesthesiology at Mayo Clinic in Rochester, MN as a Research Fellow, and he has progressed to his current appointments as Associate Professor of Anesthesiology and Professional Associate in research. He has since continued his work on the role of GTP-cyclohydrolase I and tetrahydrobiopterin in vascular endothelium and he has performed pioneering research regarding alterations of vascular tetrahydrobiopterin metabolism in cardiovascular disease.