Lukas Altwegg studied medicine in Basel and then completed a postdoctoral fellow in the cardiovascular research of the Department of Physiology, University of Zurich and worked on human connective growth factor. This was followed by further training in Internal Medicine at the Kantonsspital Baden under Prof. Hans-Jürg Beer and finally in cardiology under Prof. Thomas F. Lüscher at the University Hospital Zurich. After obtaining the FMH specialist in cardiology, he moved to Vancouver to work under Prof. John Webb, the pioneer of trans arterial valve implantation. After his return to Zurich he set up together with Prof. Willibald Maier the TAVI program. In 2012 he habilitated at the Medical Faculty of the University of Zurich and by 7 January 2013 he was elected to the St. Clara Hospital chief residency in cardiology.