Ageing of the cardiovascular system is associated with frailty and various life-threatening diseases. As global populations grow older, age-related conditions increasingly determine health span and lifespan. The circulatory system not only supplies nutrients and oxygen to all tissues of the human body and removes by-products but also builds the largest interorgan communication network...

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Artificial intelligence (AI) is set to revolutionize cardiology, offering transformative advancements in diagnosis, treatment, and patient outcomes. However, the integration of AI into clinical practice must be approached with precision and caution... 

Read full article (European Heart Journal (2025) 46, 677–679) 

At the beginning of a new year, we are full of expectations, hopes, and wishes, but also concerns and worries. This ambivalence may be appropriate for the world at large, but I would argue that the European Society of Cardiology (ESC) and its members have already embraced 2025 with enthusiasm and determination. Here are the key reasons.

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Medicine started with tender loving care, then with herbs such as foxglove as described by William Withering in 1784, and then moved to mould juice in 1928 when Alexander Fleming, at St George’s Hospital, discovered that fungal mould of the strain Penicillium rubens inhibited bacterial growth...

Read full article (European Heart Journal - Cardiovascular Pharmacotherapy (2025) 0 , 1–3) 

Coffee is part of our daily life; it is the most commonly used commodity, with an estimated 1 billion consumers worldwide. A cup of coffee, be it an Espresso, Cappuccino, or Americano, in the morning is a must for most of us in order to get going. 

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Calcific aortic valve disease (CAVD) resulting in aortic stenosis (AS) is a significant driver of cardiovascular morbidity and mortality and encompasses a spectrum of early leaflet fibrosis and thickening [aortic valve (AV) sclerosis, present in ∼25% of seniors]...

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The ESC Board 2024 - 2026 under the presidency of Prof. Thomas F. Lüscher.

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No doubt, AI will transform cardiology as it is a specialty integrating vast amounts of data on patient history, symptoms, ECGs, laboratory values, and imaging of all sorts. So, what is left for the physician?

Read full article (Cardiovascular Research (2024) 00, 1–3)

Cardiogenic shock (CS) remains the primary cause of in-hospital death after acute coronary syndromes (ACS), with its plateauing mortality rates approaching 50%. However, its sex-specific performance remains unknown, and refined risk prediction strategies are warranted.

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Circulating proenkephalin (PENK) is a stable endogenous polypeptide with fast response to glomerular dysfunction and tubular damage. This study examined the predictive value of PENK for renal outcomes and mortality in patients with acute coronary syndrome (ACS).

Read full article (European Heart Journal (2024) 00, 1–17)